The Transmedia Museum advances new approaches to the design and development of Science, Technology, Engineering and Medicine (STEM) learning in informal environments. The Museum takes shape across digital and physical platforms including an interactive digital narrative to encourage creative collaboration and critical thinking, a set of do-it-yourself maker activities and online challenges, and a tabletop kit with hands on activities for science centers and other learning hubs that promote reflections on social and ethical issues raised by emerging technologies. Through multiple activities designed to engage children and adults, the Transmedia Museum prompts participants to consider central questions raised by the novel Frankenstein that continue to inform contemporary discussions about science, technology, and society.